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Reduced TBX5 dosage causes human atrial disease by undermining developmental gene regulation of atrial cardiomyocyte identity [scATAC-seq]

GSE285168 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/12/01 Platform GPL34281Platform GPL24676
Summary
In a TBX5-linked human cellular model of atrial disease, we examined the gene networks controlled by TBX5 during human atrial differentiation using single-cell RNA and ATAC sequencing.
Published in
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
Kathiriya IS, Rao KS, Clark AP et al. · bioRxiv : the preprint server for biology 2025 · PMID 40894762 · doi:10.1101/2025.08.16.669546
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Also filed as BioProject PRJNA1201581 and SRA study SRP553176. Searching any of these in the dataset finder brings you back here.

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