← BioTransfer GEO Dataset Finder
GEO series

ATAC-seq of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice

GSE285261 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/12/28 Platform GPL30172
Summary
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF6α) remains unclear. We generated hepatocyte specific n-ATF6 overexpression transgenic mice via Cre-mediated recombination. At 3 months age, livers from the transgenic mice and their wild type controls were harvested for ATAC-sequencing.
Published in
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance
Li X, Lebeaupin C, Kadianaki A et al. · Nature 2026 · PMID 41639449 · doi:10.1038/s41586-025-10036-8
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE285261_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1202123 and SRA study SRP553485. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.