Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 6 × AML vs 4 × healthy vs 3 × molm-13 NC-circ vs 3 × molm-13 sh-circGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunityMolecular cancer · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285301_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1202189 and SRA study SRP553436. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8700430 AML1 AML
- GSM8700431 AML2 AML
- GSM8700432 AML3 AML
- GSM8700433 AML4 AML
- GSM8700434 AML5 AML
- GSM8700435 AML6 AML
- GSM8700436 healthy1 healthy
- GSM8700437 healthy2 healthy
- GSM8700438 healthy3 healthy
- GSM8700439 healthy4 healthy
- GSM8700440 molm-13 NC-circ 1 molm-13 NC-circ
- GSM8700441 molm-13 NC-circ 2 molm-13 NC-circ
- GSM8700442 molm-13 NC-circ 3 molm-13 NC-circ
- GSM8700443 molm-13 sh-circ 1 molm-13 sh-circ
- GSM8700444 molm-13 sh-circ 2 molm-13 sh-circ
- GSM8700445 molm-13 sh-circ 3 molm-13 sh-circ
- GSE180791 Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression 102 samples shares progression, promotes
- GSE316039 Downregulation of MGST3 promotes colorectal cancer progression 14 samples shares progression, promotes
- GSE270296 TGF-β Signaling Pathway and Cell-Cell Interactions in the Tumor Microenvironment Drive Bladder Cancer Progression after BCG Instillation Treatment: Insights from longitudinal Single-Nucleus RNA-Seq 14 samples shares progression, interaction
- GSE326337 Fusobacterium nucleatum FadA promotes the progression of esophageal squamous cell carcinoma through binding to TFRC 9 samples shares progression, promotes
- GSE297413 Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations 264 samples shares aml
- GSE327386 RNA-Seq of paired diagnosis and relapse AML specimens with healthy controls 130 samples shares aml
- GSE338135 NRAS knockdown reverses monocytic cell state and resensitizes resistant FLT3-AML cells to gilteritinib 75 samples shares aml
- GSE260773 RNA-seq Analysis of Acute myeloid leukemia (AML) primary samples 69 samples shares aml
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.