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Single-cell transcriptomic characterization of immune cells from hepatic tumors of wild type and ATF6 transgenic mice

GSE285366 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/28 Platform GPL24247
Summary
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF6α) remains unclear. We isolated CD45+ cells from livers tumors (induced by HDTVi) of hepatocyte-specific nATF6 overexprerssion mice receiving anti-IgG/PD1 treatment for scRNAseq to decrible the the immune cell population.
Published in
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance
Li X, Lebeaupin C, Kadianaki A et al. · Nature 2026 · PMID 41639449 · doi:10.1038/s41586-025-10036-8
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Direct links to NCBI, no account and no request form: the whole study as GSE285366_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1203229 and SRA study SRP553948. Searching any of these in the dataset finder brings you back here.

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