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Genome-Wide Mapping of E2F1 Transcription Factor Binding Sites Across Human and Epstein-Barr virus (EBV) Chromosomes

GSE285456 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/06/12 Platform GPL16791
Summary
E2F1, the first member of E2F family transcription factors, plays a central role in cell cycle progression, DNA-damage response and apoptosis. Accumulating evidence indicates that E2F1 regulates replication of several DNA viruses. We and others previously described deregulated E2F1 expression during Epstein-Barr virus (EBV) induced B-cell transformation and its role in survival of transformed B-lymphocytes in response to DNA-damage signals. In addition, global transcriptomic analyses (GSE235941, GSE237484) reveal that E2F1 expression is transcriptionally activated during EBV latent infection in B-lymphocytes but suppressed during lytic-cycle reactivation. However, the precise regulations by which E2F1 sustains EBV latent to lytic switch remains unanswered. Given that E2F activity is often deregulated by infection with DNA viruses, the main objective of our study was to investigate the genome-wide occupancy of E2F1 on both cellular and viral gene promoters, driving EBV pathogenesis.
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Also filed as BioProject PRJNA1203664 and SRA study SRP554122. Searching any of these in the dataset finder brings you back here.

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