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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D

GSE285602 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/03 Platform GPL24676
Summary
Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. However, there remains limited understanding regarding specific citrullinated proteins and their implications in the progression of RA. In this study, we screened and verified insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein and R167 was the primary citrullination site. Functional verification showed that citrullination at the R167 site of IGF2BP1 promoted the proliferation, migration and invasion of RA fibroblast-like synoviocytes (RA-FLSs). To further explore the specific downstream target of citrullinated IGF2BP1, RNA sequencing was conducted in this study.
Published in
Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D
Qin Y, Liu L, Zhang Y et al. · Communications biology 2025 · PMID 39809921 · doi:10.1038/s42003-025-07492-3
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Also filed as BioProject PRJNA1204949 and SRA study SRP554675. Searching any of these in the dataset finder brings you back here.

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