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IMMUNE-RESPONSIVE GENE 1 REGULATES ATHEROSCLEROTIC PLAQUE INFLAMMATION IIII

GSE285775 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/03 Platform GPL24676
Summary
Atherosclerosis is the major underlying cause of cardiovascular disease (CVD) mortality and is fueled by a failure to resolve inflammation within the vessel wall1. The mechanisms underpinning sustained inflammation within this microenvironment are not fully elucidated. A more comprehensive understanding of the immunoregulatory pathways modulating inflammation in this context holds the potential to inform the development of more specific therapies. Immune responsive gene 1 (Irg1) is an enzyme that diverts cis-aconitate from the TCA cycle and produces the metabolite itaconate, which elicits immunological tolerance in the context of microbial infection2–4. We hypothesized that the IRG1-itaconate axis restricts inflammation in the atherosclerotic plaque.
Published in
The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis
Cyr Y, Bozal FK, Barcia Durán JG et al. · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 38564634 · doi:10.1073/pnas.2400675121
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Also filed as BioProject PRJNA1206070 and SRA study SRP555090. Searching any of these in the dataset finder brings you back here.

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