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Piezo1 deficiency induces transcriptomic changes in HSCs [RNA-seq]

GSE285919 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/03 Platform GPL28457
Summary
We found that haematopoietic cell-specific Piezo1 knockout (KO) inhibits HSC proliferation and myeloid differentiation. To identify the underlying mechanism, we analysed the gene expression profiles of long-term haematopoietic stem cells (LT-HSCs) from Piezo1 KO mice and compared them with those from control mice. Our study demonstrated that the tight junction pathway was one of the enriched terms among downregulated genes in Piezo1 KO HSCs, with a decrease in JAM3 expression.
Published in
Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
Shang T, Zhao L, Ying S et al. · Nature aging 2026 · PMID 41482519 · doi:10.1038/s43587-025-01039-1
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Also filed as BioProject PRJNA1206981 and SRA study SRP555469. Searching any of these in the dataset finder brings you back here.

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