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IgSF11 cooperates with RAP1 to promote cell migration and invasion of cutaneous melanoma

GSE285994 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/16 Platform GPL24676
Summary
IgSF11 is a member of the immunoglobulin superfamily and is homologous to the Junction Adhesion Molecule (JAM) family. IgSF11 is expressed exclusively in the testis and central nervous system in normal adult tissues. On the other hand, ectopic expression of IgSF11 at the mRNA level has been detected in several malignant tumors, including malignant melanoma. However, the lack of highly specific antibodies has prevented functional analysis of IgSF11 in cancer. In this study, we developed a specific monoclonal antibody against IgSF11 and evaluated the IgSF11 expression of malignant melanoma cases at the protein level by immunohistochemistry. As a result, more than half of the cases showed high expression of IgSF11. In this presentation, we will show the clinical significance of IgSF11 and its molecular function in malignant melanoma cell lines.
Published in
IgSF11-RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
Kobayashi Y, Sugimoto K, Ishibashi M et al. · Cell communication and signaling : CCS 2025 · PMID 40635001 · doi:10.1186/s12964-025-02245-5
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Also filed as BioProject PRJNA1207447 and SRA study SRP555725. Searching any of these in the dataset finder brings you back here.

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