Single cell sequencing of VZV gE antigen-specific T cells with vaccination and age
Single-cell RNA-seq · human · 27 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunitybioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286045_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1207543 and SRA study SRP555856. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8716847 Exp01 CSP T cells
- GSM8716848 Exp01 GEX T cells
- GSM8716849 Exp01 TCR T cells
- GSM8716850 Exp02 CSP T cells
- GSM8716851 Exp02 GEX T cells
- GSM8716852 Exp02 TCR T cells
- GSM8716853 Exp03 CSP T cells
- GSM8716854 Exp03 GEX T cells
- GSM8716855 Exp03 TCR T cells
- GSM8716856 Exp04 CSP T cells
- GSM8716857 Exp04 GEX T cells
- GSM8716858 Exp04 TCR T cells
- GSM8716859 Exp05 CSP T cells
- GSM8716860 Exp05 GEX T cells
- GSM8716861 Exp05 TCR T cells
- GSM8716862 Exp06 CSP T cells
- GSM8716863 Exp06 GEX T cells
- GSM8716864 Exp06 TCR T cells
- GSM8716865 Exp07 CSP T cells
- GSM8716866 Exp07 GEX T cells
- GSM8716867 Exp07 TCR T cells
- GSM8716868 Exp09 CSP T cells
- GSM8716869 Exp09 GEX T cells
- GSM8716870 Exp09 TCR T cells
- GSM8716871 Exp10 CSP T cells
- GSM8716872 Exp10 GEX T cells
- GSM8716873 Exp10 TCR T cells
- GSE249632 Longitudinal analysis of antigen-specific T cells after Shingrix vaccination 2866 samples shares antigen-specific, vaccination
- GSE247488 Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection. 15 samples shares antigen-specific, vaccination
- GSE260763 Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics 60 samples shares vaccination
- GSE206641 HBVAF cells treated with exosomes from VZV-infected neurons 6 samples shares vzv
- GSE266519 Hematopoietic Stem Cell Transplant and Healthy Donor Single cell RNA-seq (scRNA-seq) combined with T Cell Receptor (TCR) and B Cell Receptor (BCR) sequencing on Timepoints Surrounding SARS-CoV-2 Vaccination and Infection 48 samples shares vaccination
- GSE275633 BEAM-T single cell sequencing of antigen-specific memory CD8+ T cell with age 24 samples shares antigen-specific
- GSE210231 CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance 931 samples shares vaccination
- GSE176022 Distinct transcriptional programs characterize neoantigen-specific T cells in lung cancers treated with neoadjuvant PD-1 blockade [bulk TCR-seq] 102 samples shares antigen-specific
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.