TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway[II]
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 × Medical Cartilage vs 8 × Lateral CartilageGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286154_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1208007 and SRA study SRP556074. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8718799 Medical Cartilage 1 Medical Cartilage
- GSM8718800 Medical Cartilage 2 Medical Cartilage
- GSM8718801 Medical Cartilage 3 Medical Cartilage
- GSM8718802 Medical Cartilage 4 Medical Cartilage
- GSM8718803 Medical Cartilage 5 Medical Cartilage
- GSM8718804 Medical Cartilage 6 Medical Cartilage
- GSM8718805 Medical Cartilage 7 Medical Cartilage
- GSM8718806 Medical Cartilage 8 Medical Cartilage
- GSM8718807 Lateral Cartilage 1 Lateral Cartilage
- GSM8718808 Lateral Cartilage 2 Lateral Cartilage
- GSM8718809 Lateral Cartilage 3 Lateral Cartilage
- GSM8718810 Lateral Cartilage 4 Lateral Cartilage
- GSM8718811 Lateral Cartilage 5 Lateral Cartilage
- GSM8718812 Lateral Cartilage 6 Lateral Cartilage
- GSM8718813 Lateral Cartilage 7 Lateral Cartilage
- GSM8718814 Lateral Cartilage 8 Lateral Cartilage
- GSE338020 Sturgeon Cartilage–Derived Peptides Promote Cartilage Repair-Associated Responses in Osteoarthritis via Integrin αvβ3–PI3K/Akt Signaling 12 samples shares pi3k, akt, osteoarthritis
- GSE322526 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress 30 samples shares pi3k, akt
- GSE260759 Targeting a Lineage-Specific PI3Kɣ/AKT Signaling Module in Acute Myeloid Leukemia Using a Heterobifunctional Degrader Molecule 24 samples shares pi3k, akt
- GSE269369 LIN28B-mediated activation of the PI3K/AKT pathway promotes metastasis and unravels a new therapeutic vulnerability in colorectal cancer 18 samples shares pi3k, akt
- GSE322525 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq] 18 samples shares pi3k, akt
- GSE289892 Acetaldehyde Induced Cell Damage and Genotoxic Effects by Modulating PI3K/AKT and MAPK/ERK Pathways in Human Lung Epithelial Cells 17 samples shares pi3k, akt
- GSE316535 POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma 14 samples shares pi3k, akt
- GSE269696 Overexpressed PRR11-SKA2-miR301a/454 bidirectional transcription unit essentially and coordinately promotes PI3K-AKT pathway activation and lung cancer progression 13 samples shares pi3k, akt
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.