FOXP3 Expression Depends on Cell-Type Specific Cis-Regulatory Element and Transcription Factor Circuitry
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 95 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 95 samples: 93 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitryImmunity · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286473_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1209559 and SRA study SRP556757. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 95 sample titles: 93 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8728218 Tconv FOXP3 low bin, Donor 1, CRISRP KO TF screen
- GSM8728219 Tconv FOXP3 high bin, Donor 1, CRISRP KO TF screen
- GSM8728220 Tconv FOXP3 low bin, Donor 2, CRISRP KO TF screen
- GSM8728221 Tconv FOXP3 high bin, Donor 2, CRISRP KO TF screen
- GSM8728222 Tconv FOXP3 low bin, Donor 3, CRISRP KO TF screen
- GSM8728223 Tconv FOXP3 high bin, Donor 3, CRISRP KO TF screen
- GSM8728224 Treg FOXP3 low bin, Donor 1, CRISRP KO TF screen
- GSM8728225 Treg FOXP3 high bin, Donor 1, CRISRP KO TF screen
- GSM8728226 Treg FOXP3 low bin, Donor 2, CRISRP KO TF screen
- GSM8728227 Treg FOXP3 high bin, Donor 2, CRISRP KO TF screen
- GSM8728228 Tconv FOXP3 low bin, Donor 1, CRISRPi screen
- GSM8728229 Tconv FOXP3 high bin, Donor 1, CRISRPi screen
- GSM8728230 Tconv FOXP3 low bin, Donor 3, CRISRPi screen
- GSM8728231 Tconv FOXP3 high bin, Donor 3, CRISRPi screen
- GSM8728232 Treg FOXP3 low bin, Donor 1, CRISRPi screen
- GSM8728233 Treg FOXP3 high bin, Donor 1, CRISRPi screen
- GSM8728234 Treg FOXP3 low bin, Donor 2, CRISRPi screen
- GSM8728235 Treg FOXP3 high bin, Donor 2, CRISRPi screen
- GSM9161587 Human Tconv stim, Donor 1, CRISPRoff AAVS1, gRNA gJ-48
- GSM9161588 Human Tconv stim, Donor 1, CRISPRoff AAVS1, gRNA gJ-49
- GSM9161589 Human Tconv stim, Donor 1, CRISPRoff NS-, gRNA gJ-53
- GSM9161590 Human Tconv stim, Donor 2, CRISPRoff AAVS1, gRNA gJ-48
- GSM9161591 Human Tconv stim, Donor 2, CRISPRoff AAVS1, gRNA gJ-49
- GSM9161592 Human Tconv stim, Donor 2, CRISPRoff NS-, gRNA gJ-53
- GSM9161593 Human Tconv rest, Donor 1, GATA3-abcam ChIP, DSG/formaldehyde fixation
- GSM9161594 Human Tconv rest, Donor 1, YY1-abcam ChIP, DSG/formaldehyde fixation
- GSM9161595 Human Tconv rest, Donor 1, YY1-active-motif ChIP, DSG/formaldehyde fixation
- GSM9161596 Human Tconv rest, Donor 1, CTCF ChIP, DSG/formaldehyde fixation
- GSM9161597 Human Tconv rest, Donor 1, MBD2 ChIP, DSG/formaldehyde fixation
- GSM9161598 Human Tconv rest, Donor 1, EGR2 ChIP, DSG/formaldehyde fixation
- GSM9161599 Human Tconv rest, Donor 1, SATB1 ChIP, DSG/formaldehyde fixation
- GSM9161600 Human Tconv rest, Donor 1, H3K27ac ChIP, DSG/formaldehyde fixation
- GSM9161601 Human Tconv stim, Donor 1, GATA3-abcam ChIP, DSG/formaldehyde fixation
- GSM9161602 Human Tconv stim, Donor 1, YY1-abcam ChIP, DSG/formaldehyde fixation
- GSM9161603 Human Tconv stim, Donor 1, YY1-active-motif ChIP, DSG/formaldehyde fixation
- GSM9161604 Human Tconv stim, Donor 1, CTCF ChIP, DSG/formaldehyde fixation
- GSM9161605 Human Tconv stim, Donor 1, MBD2 ChIP, DSG/formaldehyde fixation
- GSM9161606 Human Tconv stim, Donor 1, EGR2 ChIP, DSG/formaldehyde fixation
- GSM9161607 Human Tconv stim, Donor 1, SATB1 ChIP, DSG/formaldehyde fixation
- GSM9161608 Human Tconv stim, Donor 1, FOXP3 ChIP, DSG/formaldehyde fixation
+ 55 more — browse all 95 samples with per-sample file links →
- GSE256232 Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq 67 samples shares cis-regulatory, transcription, element
- GSE51334 DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions 993 samples shares cell-type, specific
- GSE292300 A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer: ChIP-seq 76 samples shares transcription, circuitry
- GSE292302 A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer: RNA-seq 42 samples shares transcription, circuitry
- GSE303605 Rbm5 Sustains Leukemia Stem Cells Through a Myc-driven Transcriptional Circuitry 15 samples shares transcription, circuitry
- GSE253419 Tissue-specific immune transcriptional signatures in the bordering tissues of the mouse brain and retina 3 samples shares transcription, specific
- GSE253096 Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity 20 samples shares foxp3
- GSE256246 Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function. 132 samples shares transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.