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CUL4B and KDM5B ChIP-sequencing in MCF-7 cells

GSE286885 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/02/18 Platform GPL24676
Summary
Estrogen receptor-positive (ER+) breast cancer is the predominant subtype of breast cancer. Here, we investigate the functional interplay between lysine demethylase 5B (KDM5B) and the Cullin-RING ligase 4B (CRL4B) complex in modulating cholesterol metabolism to promote ER+ breast cancer progression. We found that disrupting the KDM5B–CRL4B axis impairs cholesterol homeostasis and inhibits tumor growth.
Published in
KDM5B cooperates with CRL4B complex to promote the tumorigenesis of ER+ breast cancer via regulating cholesterol metabolism
Yang Y, Gao T, Yuan B et al. · Cell death & disease 2026 · PMID 41654562 · doi:10.1038/s41419-026-08438-1
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Also filed as BioProject PRJNA1210487 and SRA study SRP557205. Searching any of these in the dataset finder brings you back here.

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