GEO series
Characterization of the TREM-1 Signaling Landscape in Human Neutrophils
GSE286969
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/03/11
GPL24676
Summary
The Triggering Receptor Expressed on Myeloid Cells (TREM)-1 is a member of the Immunoglobulin superfamily. Beyond its role in acute and chronic inflammatory processes, TREM-1 is also involved in cancer emergence and progression. Advanced information about the TREM-1 signaling cascade may reveal novel targets for treating inflammatory and cancer diseases. We investigated the transcriptomic profile of PMN after TREM-1 ligation that made us available to link the previously analyzed kinome activity to the resulting transcriptomic profile. In sum, we revealed several signaling pathways being active after TREM-1 ligation that are associated with various biological processed and diseases.
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Paper (PMID 41785288) ↗
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