RNA-Seq analysis of germinal center B cells from Tfr-depleted and control kidney transplant recipients
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × Con GC vs 5 × DTR GCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cellsNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286974_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1210623 and SRA study SRP557284. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8735105 Con GC 1 Con GC
- GSM8735106 Con GC 2 Con GC
- GSM8735107 Con GC 3 Con GC
- GSM8735108 Con GC 4 Con GC
- GSM8735109 Con GC 5 Con GC
- GSM8735110 DTR GC 1 DTR GC
- GSM8735111 DTR GC 2 DTR GC
- GSM8735112 DTR GC 3 DTR GC
- GSM8735113 DTR GC 4 DTR GC
- GSM8735114 DTR GC 5 DTR GC
- GSE317658 Translational control of germinal center response and plasma cell differentiation by RNA helicase Dhx29 18 samples shares germinal, control, center
- GSE298425 T cell help transiently unlocks a high plasticity state in germinal center B cells during the humoral immune response [ActB_RNA-seq] 15 samples shares germinal, rna-seq, center
- GSE264163 RNA-seq and ATAC-seq of follicular B cells and germinal center B cells with a conditional deletion of Brwd1 12 samples shares germinal, rna-seq, center
- GSE275669 RNA binding protein Pcbp1 maintains mitochondria integrity to promote antibody production and germinal center response[RNA-seq] 10 samples shares germinal, rna-seq, center
- GSE312596 RNA-seq analysis of germinal center-derived splenic IgG1 or IgM plasma cells 10 samples shares germinal, rna-seq, center
- GSE184075 RNA-seq analysis of gene expression profile in Setd2 WT and KO germinal center B cells and Phf19 WT and KO germinal center B cells 6 samples shares germinal, rna-seq, center
- GSE230528 Analysis of transcriptomes of germinal center (GC) B cells derived from miR-155-sufficient and -deficient mice at the single-cell level [scRNA-seq] 6 samples shares germinal, rna-seq, center
- GSE249427 T cell help transiently unlocks a high plasticity state in germinal center B cells during the humoral immune response [Foxo1_RNA-seq] 6 samples shares germinal, rna-seq, center
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.