Epigenetic landscape of synthetic human centromeres: Euchromatic modifications coexist interdependently at CENP-A dense regions and prevent intrusion of other modifications [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 102 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 102 samples: 49 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic landscape of synthetic human centromere core regions: CENP-A assembly and euchromatic modifications interdependently antagonize heterochromatin accumulationNucleic acids research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287042_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1211039 and SRA study SRP557684. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 102 samples.
How we read this: 49 replicated groups read from 102 sample titles; they account for 102 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8736893 ChIP CENPA 120 ChIP CENPA
- GSM8736894 ChIP CENPA 18 ChIP CENPA
- GSM8736895 ChIP CENPA 42 ChIP CENPA
- GSM8736896 ChIP CENPA 465 ChIP CENPA
- GSM8736897 ChIP CENPA 36 ChIP CENPA
- GSM8736898 ChIP CENPA 449 ChIP CENPA
- GSM8736899 ChIP H3K4me2 120 ChIP H3K4me2
- GSM8736900 ChIP H3K14ac 120 ChIP H3K14ac
- GSM8736901 ChIP H4K8ac 120 ChIP H4K8ac
- GSM8736902 ChIP K4K20me1 120 ChIP K4K20me1
- GSM8736903 ChIP H3K36me2 120 ChIP H3K36me2
- GSM8736904 ChIP H3K9me3 120 ChIP H3K9me3
- GSM8736905 ChIP H3K4me2 465 ChIP H3K4me2
- GSM8736906 ChIP H3K14ac 465 ChIP H3K14ac
- GSM8736907 ChIP H4K8ac 465 ChIP H4K8ac
- GSM8736908 ChIP K4K20me1 465 ChIP K4K20me1
- GSM8736909 ChIP H3K36me2 465 ChIP H3K36me2
- GSM8736910 ChIP H3K9me3 465 ChIP H3K9me3
- GSM8736911 ChIP THYM CENPA 120 ChIP THYM CENPA
- GSM8736912 ChIP THYM H3K4me2 120 ChIP THYM H3K4me2
- GSM8736913 ChIP THYM H3K14ac 120 ChIP THYM H3K14ac
- GSM8736914 ChIP THYM H4K8ac 120 ChIP THYM H4K8ac
- GSM8736915 ChIP THYM K4K20me1 120 ChIP THYM K4K20me1
- GSM8736916 ChIP THYM H3K36me2 120 ChIP THYM H3K36me2
- GSM8736917 ChIP THYM H3K9me3 120 ChIP THYM H3K9me3
- GSM8736918 ChIP COL CENPA 120 ChIP COL CENPA
- GSM8736919 ChIP COL H3K4me2 120 ChIP COL H3K4me2
- GSM8736920 ChIP COL H3K14ac 120 ChIP COL H3K14ac
- GSM8736921 ChIP COL H4K8ac 120 ChIP COL H4K8ac
- GSM8736922 ChIP COL K4K20me1 120 ChIP COL K4K20me1
- GSM8736923 ChIP COL H3K36me2 120 ChIP COL H3K36me2
- GSM8736924 ChIP COL H3K9me3 120 ChIP COL H3K9me3
- GSM8736925 ChIP CR3 CENPA 120 ChIP CR3 CENPA
- GSM8736926 ChIP CR3 H3K4me2 120 ChIP CR3 H3K4me2
- GSM8736927 ChIP CR3 H3K14ac 120 ChIP CR3 H3K14ac
- GSM8736928 ChIP CR3 H4K8ac 120 ChIP CR3 H4K8ac
- GSM8736929 ChIP CR3 K4K20me1 120 ChIP CR3 K4K20me1
- GSM8736930 ChIP CR3 H3K36me2 120 ChIP CR3 H3K36me2
- GSM8736931 ChIP CR3 H3K9me3 120 ChIP CR3 H3K9me3
- GSM8736932 ChIP THYM CENPA 465 ChIP THYM CENPA
+ 62 more — browse all 102 samples with per-sample file links →
- GSE287041 Epigenetic landscape of synthetic human centromeres: Euchromatic modifications coexist interdependently at CENP-A dense regions and prevent intrusion of other modifications [RNA-seq] 4 samples shares cenp-a, interdependently, modifications, centromeres, euchromatic, epigenetic, synthetic, intrusion
- GSE336584 Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation 60 samples shares cenp-a, centromeres
- GSE244792 AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scATAC-seq] 31 samples shares modifications, epigenetic
- GSE216821 Histone H3 epigenetic modifications 12 samples shares modifications, epigenetic
- GSE216817 Histone H3 epigenetic modifications ChIPseq 4 samples shares modifications, epigenetic
- GSE216818 Histone H3 epigenetic modifications ChIPseq K27me3 4 samples shares modifications, epigenetic
- GSE282301 Histone H3 epigenetic modifications ChIPseq [men] 3 samples shares modifications, epigenetic
- GSE244795 AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes 107 samples shares modifications, epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.