GEO series
Effect of glutamine supplementation on naïve CD4 T cell differentiation from CARD11 R75W mutation patients
GSE287077
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2025/01/20
GPL34295
Summary
CARD11 LOF mutant patients develop severe atopic phenotpes and increased T-helper 2 (Th2) cytokine production, in addition to other immunopathology. CARD11 LOF impairs lymphocyte receptor–mediated glutamine uptake—thereby reducing signaling in mTORC1. Herein, we investigate whether exogenous glutamine treatment would alleviate Th2 phenotypes of CARD11 LOF mutant T cells.
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Paper (PMID 40111223) ↗
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