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Multiomics identifies unique modulators of calf muscle pathophysiology in peripheral artery disease and chronic kidney disease

GSE287118 Homo sapiens (human) RNA-seq (gene expression) 86 samples Submitted 2026/01/30 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 86 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
86 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Multiomic Analysis of Calf Muscle in Peripheral Artery Disease and Chronic Kidney DiseaseCirculation research · 2025
Summary (written by the submitters)
This project aimed to map transcriptome changes in the skeletal muscle of patients with and without PAD (peripheral artery disease) and CKD (chronic kidney disease)
Published in
Multiomic Analysis of Calf Muscle in Peripheral Artery Disease and Chronic Kidney Disease
Kim K, Thome T, Pass C et al. · Circulation research 2025 · PMID 39963788 · doi:10.1161/CIRCRESAHA.124.325642
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287118_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1211145 and SRA study SRP557631. Searching any of these in the dataset finder brings you back here.

Study design
A cohort of 86 individual samples

The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Sample titles run PAD201 … PAD321 and carry no group information.

Samples in this study

+ 46 more — browse all 86 samples with per-sample file links →

Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.