GEO series

Developmental reprogramming of the melanocortin neurons regulates energy homeostasis

GSE287161 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 12 samples Submitted 2026/02/16 Platform GPL30172Platform GPL28330

At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples

What it is: ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism: Mus musculus (mouse)
Samples: 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper: Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in miceNeuron · 2026

Summary (written by the submitters)

The central melanocortin neurons regulate satiety in mammalian species. Proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARH) play crucial and opposing roles in regulating food intake. POMC neurons promote satiety by releasing the anorexigenic peptide α-melanocyte-stimulating hormone (α-MSH), while AgRP neurons promote hunger through the release of the orexigenic peptides AgRP and neuropeptide Y (NPY).

Read the full summary ↓

While distinct in function, these neurons arise, in part, from shared neuronal precursors during development. In mice, Pomc mRNA first appears in the developing hypothalamus at embryonic (E) day E10.5. The number of Pomc-expressing neurons gradually increases, reaching a peak around E13.5. However, Pomc expression in these neurons does not dictate terminal cell fate; instead, more than half of them lose Pomc expression as they adopt other peptidergic identities by the early postnatal period. Remarkably, some Pomc precursors begin expressing Npy, a marker for AgRP neurons, giving rise to a subset of adult AgRP neurons. However, the molecular mechanisms governing the fate switch between two antagonistic feeding neurons, and its physiological implications, have remained unknown.

Published in

Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in mice

Xu B, Li L, Chen M et al. · Neuron 2026 · PMID 41702397 · doi:10.1016/j.neuron.2025.12.022

This dataset

Open GSE287161 in finder → Find more mouse ChIP / ATAC / CUT&Tag datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287161_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1211524 and SRA study SRP557831. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41702397) ↗

Study design

12 samples, each with a distinct title — no replicated groups

Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM8740244 10xMulti_Pomc_2_GEX
GSM8740245 10xMulti_Pomc_2_ATAC
GSM8740246 10xMulti_Pomc_2_HTO
GSM8740247 10xMulti_Pomc_3_GEX
GSM8740248 10xMulti_Pomc_3_ATAC
GSM8740249 10xMulti_Pomc_3_HTO
GSM8740250 10xMulti_Pomc_4_GEX
GSM8740251 10xMulti_Pomc_4_ATAC
GSM8740252 10xMulti_Pomc_4_HTO
GSM8740253 10xMulti_Pomc_5_GEX
GSM8740254 10xMulti_Pomc_5_ATAC
GSM8740255 10xMulti_Pomc_5_HTO

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.