Adipose tissue gene expression profiling in women with overweight or obesity following early vs. late time-restricted eating

Time-restricted eating (TRE) is a promising strategy to prevent obesity and type 2 diabetes, but data on its effects on adipose tissue metabolism are limited. Therefore, we conducted a crossover study examined 31 women with overweight or obesity who followed both a two-week early TRE (eTRE) and a two-week late TRE (lTRE). Gene expression profiles in subcutaneous adipose tissue collected after both TRE interventions were compared using RNA sequencing. These data provide a first insight into the remodelling of the human adipose tissue transcriptome by the eating timing during TRE, warranting consideration in future dietary research and recommendations.