GEO series
FeaSion Decodes the Regulatory Landscape and Functional Diversity of RNA Polymerase II CTD Phosphorylation
GSE287316
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
167 samples
2025/10/28
GPL29480GPL30209GPL24676
Summary
We utilize the FeaSion (Feature-Screening-Function) strategy to investigate five known phosphorylation states (pY1, pS2, pT4, pS5, pS7) of RNAPII. Our study demonstrates that mutations at these phosphorylation sites broadly influence transcriptional and co-transcriptional processes. And regulators of these sites involve various biological processes.
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