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Intracellular traction forces modulate chromatin accessibility at the FOXO1 locus

GSE287556 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/11/23 Platform GPL34281
Summary
In summary, our study demonstrates that cellular traction forces modulate cellular senescence by promoting chromatin accessibility, particularly at regions associated with FOXO1 expression. This localized chromatin remodeling facilitates FOXO1 activation, which serves as a critical mediator linking cell mechanics to transcriptional and functional changes that regulate senescence. These findings highlight the role of mechanical forces in orchestrating chromatin dynamics and underscore FOXO1 as a key target in the mechanotransduction-mediated regulation of aging.
Published in
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
Liu X, Ye Y, Li Z et al. · Nature communications 2026 · PMID 41526350 · doi:10.1038/s41467-026-68387-3
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Also filed as BioProject PRJNA1213737 and SRA study SRP558694. Searching any of these in the dataset finder brings you back here.

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