A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signalScience advances · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287784_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1214692 and SRA study SRP559367. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 8 replicated groups read from 21 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8751344 HSCs, Etv6 S211I P216L, Rep1 HSCs, Etv6 S211I P216L,
- GSM8751345 HSCs, Etv6 S211I P216L, Rep 2 HSCs, Etv6 S211I P216L,
- GSM8751346 HSCs, Etv6 S211I P216L, Rep 3 HSCs, Etv6 S211I P216L,
- GSM8751347 HSCs, Etv6 P216L, Rep 1 HSCs, Etv6 P216L,
- GSM8751348 HSCs, Etv6 P216L, Rep 2 HSCs, Etv6 P216L,
- GSM8751349 HSCs, Etv6 P216L, Rep 3 HSCs, Etv6 P216L,
- GSM8751350 HSCs, Etv6 S211I, Rep 1 HSCs, Etv6 S211I,
- GSM8751351 HSCs, Etv6 S211I, Rep 2 HSCs, Etv6 S211I,
- GSM8751352 HSCs, WT, Rep 1 HSCs, WT,
- GSM8751353 HSCs, WT, Rep 2 HSCs, WT,
- GSM8751354 HSCs, WT, Rep 3 HSCs, WT,
- GSM8751355 MEPs, Etv6 S211I P216L, Rep1 MEPs, Etv6 S211I P216L,
- GSM8751356 MEPs, Etv6 S211I P216L, Rep 2 MEPs, Etv6 S211I P216L,
- GSM8751357 MEPs, Etv6 S211I P216L, Rep 3 MEPs, Etv6 S211I P216L,
- GSM8751358 MEPs, Etv6 P216L, Rep 1 MEPs, Etv6 P216L,
- GSM8751359 MEPs, Etv6 P216L, Rep 2 MEPs, Etv6 P216L,
- GSM8751360 MEPs, Etv6 P216L, Rep 3 MEPs, Etv6 P216L,
- GSM8751361 MEPs, Etv6 S211I, Rep 1 MEPs, Etv6 S211I,
- GSM8751362 MEPs, Etv6 S211I, Rep 2 MEPs, Etv6 S211I,
- GSM8751363 MEPs, WT, Rep 1 MEPs, WT,
- GSM8751364 MEPs, WT, Rep 3 MEPs, WT,
- GSE276312 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [scRNA-seq] 23 samples shares hematopoiesis, mutation
- GSE229427 Tracking spatio-temporal dynamics of the endothelial niche during fetal hematopoiesis 216 samples shares hematopoiesis
- GSE215960 Subclonal evolution revealed by single-cell profiles of expressed mutations identifies adaptation mechanisms to immunotherapy in melanoma [scRNA-seq] 192 samples shares mutation
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares germline
- GSE180529 A Dominant mutation in Dnmt1 leads epigenetic changes (Bulk RNAseq) 92 samples shares mutation
- GSE260623 Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma [bulkRNA] 91 samples shares germline
- GSE276784 Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche 89 samples shares hematopoiesis
- GSE283659 Skeletal dysplasia-causing mutations in TRPV4 alter the chondrocyte’s transcriptomic response to mechanical loading 71 samples shares mutation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.