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Human BM-MSC and BM-neurosphere transplantation shows limited efficacy as a therapeutic adjunct to surgical decompression in an implantable polymer-induced DCM model.

GSE287931 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/29 Platform GPL24676
Summary
Human bone marrow-derived marrow stromal cell (BM-MSC) and neurosphere (BM-neurosphere) transplantation shows limited efficacy as a therapeutic adjunct to surgical decompression in an implantable polymer-induced degenerative cervical myelopathy (DCM) model Degenerative cervical myelopathy (DCM) is a prevalent spinal cord disorder in the developed world. The study investigates the therapeutic potential of human bone marrow-derived mesenchymal stem cells (BM-MSC) and BM-neurospheres as adjunct therapies to surgical decompression in a polymer-induced DCM rat model. The study assessed locomotor function, blood-spinal cord barrier (BSCB) integrity, and cell engraftment. Results showed delayed locomotor recovery upon cervical decompression and limited efficacy of BM-MSCs and BM-neurospheres in improving outcomes under the experimental conditions.
Published in
A preclinical study on cell therapy as an adjunct to surgical decompression in degenerative cervical myelopathy via accelerating blood spinal cord barrier reconstitution and neurological recovery
Kim HW, Shi LY, Lee MG et al. · Stem cell research & therapy 2025 · PMID 40437637 · doi:10.1186/s13287-025-04348-9
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Also filed as BioProject PRJNA1215316 and SRA study SRP559663. Searching any of these in the dataset finder brings you back here.

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