← BioTransfer GEO Dataset Finder
GEO series

Gene expression profiling of 22Rv1 cells treated with a CDK9 degrader, Compound 45 (D45)

GSE288031 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/27 Platform GPL29480
Summary
As one of the serine/threonine protein kinase family members, Cyclin-dependent kinase 9 (CDK9) functions as a critical regulator of transcription. Its overexpression has been observed in various cancers, including prostate cancer, positioning it as a potential therapeutic target. D45, a newly developed small molecular CDK9 degrader, has been shown to significantly inhibit the growth of triple-negative breast cancer cells. Currently, we carried out a study to explore the role of CDK9 in castration-resistant prostate cancer (CRPC). Hence, human CRPC 22Rv1 cells were treated with small molecule compound, D45, targeting CDK9, followed by RNA-sequencing.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE288031_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1215747 and SRA study SRP559906. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.