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Transcriptional Heterogeneity of Progression in MYOD1-mutant spindle cell rhabdomyosarcoma

GSE288065 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2026/01/22 Platform GPL18573
Summary
We perform single nuclei transcriptomics (snRNA-seq) analysis of patient-derived tumor samples to define the dynamic myogenic cell states and intratumoral transcriptional heterogeneity of MYOD1-mutant spindle cell/sclerosing rhabdomyosarcoma.
Published in
Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma
Dermawan JK, Vanoli F, de Traux de Wardin H et al. · Science advances 2026 · PMID 41758938 · doi:10.1126/sciadv.aea6453
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Also filed as BioProject PRJNA1215984 and SRA study SRP560017. Searching any of these in the dataset finder brings you back here.

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