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RNA-Seq of doxorubicin treated rats and vehicle control

GSE288168 Rattus norvegicus (rat) RNA-seq (gene expression) 6 samples Submitted 2025/03/14 Platform GPL25947
At a glance

RNA-seq (gene expression) · rat · 6 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Rattus norvegicus (rat)
Samples
6 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
Despite significant advancements in the oncologic field, cancer remains a major cause of concern for global health. Doxorubicin is a member of the anthracycline class of chemotherapeutic agents which remains among the most effective treatment available up to date. However, its clinical use is significantly limited by severe cardiotoxic effects.
Read the full summary ↓
The purpose of this study is to investigate the transcriptomic alterations that occur in a rat model of doxorubicin-induced cardiotoxicity. Our results reveal significant dysregulation of cardiac metabolism and provide insights into the molecular mechanisms underlying cardiac damage produced by this treatment.
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288168_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1216320 and SRA study SRP560268. Searching any of these in the dataset finder brings you back here.

Samples in this study

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+ 6 more — browse all 6 samples with per-sample file links →

Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.