Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development
RNA-seq (gene expression) · mouse · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 30 samples: 13 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell developmentNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288186_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216537 and SRA study SRP560242. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 26 samples.
How we read this: 13 replicated groups read from 30 sample titles; they account for 26 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8760095 D2-EV1 D2-EV
- GSM8760096 D2-EV2 D2-EV
- GSM8760097 D2-OE1 D2-OE
- GSM8760098 D2-OE2 D2-OE
- GSM8760099 D2-C1 D2-C
- GSM8760100 D2-C2 D2-C
- GSM8760101 D2-dATG1
- GSM8760102 D2-dTAG2
- GSM8760103 D6-EV1 D6-EV
- GSM8760104 D6-EV2 D6-EV
- GSM8760105 D6-OE1 D6-OE
- GSM8760106 D6-OE2 D6-OE
- GSM8760107 C_spg_rep1 C_spg
- GSM8760108 C_sctMI_rep1 C_sctMI
- GSM8760109 C_sctMII_rep1 C_sctMII
- GSM8760110 C_RS_rep1 C_RS
- GSM8760111 C_spg_rep2 C_spg
- GSM8760112 C_sctMI_rep2 C_sctMI
- GSM8760113 C_sctMII_rep2 C_sctMII
- GSM8760114 C_RS_rep2 C_RS
- GSM8760115 KO_spg_rep1 KO_spg
- GSM8760116 KO_spg_rep2 KO_spg
- GSM8760117 KO_sctMI_rep1 KO_sctMI
- GSM8760118 KO_sctMI_rep2 KO_sctMI
- GSM8760119 KO_sctMII_rep1 KO_sctMII
- GSM8760120 KO_sctMII_rep2 KO_sctMII
- GSM8760121 KO_RS_rep1 KO_RS
- GSM8760122 KO_RS_rep2 KO_RS
- GSM8760125 D2EB
- GSM8760126 dD2EB
- GSE288151 Transcriptional changes of Tex10 in purified primordial gem cell-like cells (PGCLCs) at day2 and day6 12 samples shares tex10, primordial
- GSE289335 TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [bulkRNA-seq, scRNA-seq] 127 samples shares primordial, germ
- GSE287234 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [RNA-seq] 36 samples shares primordial, germ
- GSE270036 Investigate the functions of core pluripotency transcription factors in embryonic stem cells 30 samples shares pluripotency, factor
- GSE253473 FoxO transcription factors actuate the formative pluripotency specific gene expression programme [RNA-Seq] 26 samples shares pluripotency, factor
- GSE300734 Brg1 defect causes aberrent nucleosome landscape and affects totipotency & pluripotency transcriptional factors binding during embryogenesis [RNA-seq] 25 samples shares pluripotency, factor
- GSE318472 Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage 16 samples shares spermatogenesis, germ
- GSE240967 UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells [RNAseq_PGCs] 16 samples shares primordial, germ
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.