Replication stress responses in human lymphocytes change sex-specifically during aging
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Replication stress responses in human lymphocytes change sex-specifically during agingNucleic acids research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288191_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216548. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8760970 P160, PBL, female, young
- GSM8760971 P163, PBL, female, young
- GSM8760972 P172, PBL, female, young
- GSM8760973 P173, PBL, female, young
- GSM8760974 P174, PBL, female, young
- GSM8760975 P175, PBL, female, young
- GSM8760976 P164, PBL, male, young
- GSM8760977 P166, PBL, male, young
- GSM8760978 P168, PBL, male, young
- GSM8760979 P170, PBL, male, young
- GSM8760980 P171, PBL, male, young
- GSM8760981 P181, PBL, male, young
- GSM8760982 P165, PBL, female, old
- GSM8760983 P167, PBL, female, old
- GSM8760984 P184, PBL, female, old
- GSM8760985 P185, PBL, female, old
- GSM8760986 P186, PBL, female, old
- GSM8760987 P190, PBL, female, old
- GSM8760988 P182, PBL, male, old
- GSM8760989 P183, PBL, male, old
- GSM8760990 P187, PBL, male, old
- GSM8760991 P188, PBL, male, old
- GSM8760992 P189, PBL, male, old
- GSM8760993 P195, PBL, male, old
- GSE268776 Multi-omics approaches reveal that Diffuse Midline Gliomas are susceptible to replication stress therapy and cholesterol biosynthesis inhibition [RNA-seq] 64 samples shares replication, stress
- GSE292798 Transcriptomic signatures in peripheral CD4 + T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation 24 samples shares lymphocytes, aging
- GSE322525 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq] 18 samples shares replication, stress
- GSE281129 Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer 794 samples shares replication, stress
- GSE271990 Replication Stress Causes Mitotic Nuclear Envelope Reassembly Defect 36 samples shares replication, stress
- GSE298728 SLX4IP limits replication stress globally and at ALT telomeres 16 samples shares replication, stress
- GSE241261 Integrated analysis of transcriptional and metabolic responses to mitochondrial stress 72 samples shares stress
- GSE303084 Pressure Points: Endothelial Responses to Hemodynamic Stress in Health and Pulmonary Arterial Hypertension 72 samples shares stress
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.