← BioTransfer GEO Dataset Finder
GEO series

A distinct follicular helper CD4 T cell programming characterizes neutralization activity in chronic HIV infection

GSE288212 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/01 Platform GPL23227
Summary
A subset of people living with HIV (PLWH) can generate broadly neutralizing antibodies (bNAbs), yet the cellular and molecular dynamics within the lymph nodes (LNs) that facilitate this process remain unclear. To investigate these mechanisms, we performed single-cell RNA sequencing (scRNA-seq) on CD45+ cells isolated from LNs of ART-naïve PLWH who produce bNAbs. Comparative analyses revealed distinct transcriptional profiles and cellular compositions between the two groups. Our data identified potential molecular mediators of TFH-B cell interactions that are unique to neutralizers. Together, these findings provide new insights into the germinal center dynamics and immune cell networks underlying bNAb development in PLWH.
Published in
Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus
Georgakis S, Ioannidou K, Mora BB et al. · Frontiers in immunology 2025 · PMID 40070830 · doi:10.3389/fimmu.2025.1530327
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE288212_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1216578 and SRA study SRP560377. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.