A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A basophil-fibroblast pro-inflammatory axis fuels type 2 skin inflammationCell reports · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288255_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216627 and SRA study SRP560257. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8760226 cKO_sample1 cKO_sample
- GSM8760227 cKO_sample2 cKO_sample
- GSM8760228 cKO_sample3 cKO_sample
- GSM8760229 IL4RA_ff_sample1 IL4RA_ff_sample
- GSM8760230 IL4RA_ff_sample2 IL4RA_ff_sample
- GSM8760231 IL4RA_ff_sample3 IL4RA_ff_sample
- GSM8760232 Isotype_sample1 Isotype_sample
- GSM8760233 Isotype_sample2 Isotype_sample
- GSM8760234 Isotype_sample3 Isotype_sample
- GSM8760235 MAR1_sample1 MAR1_sample
- GSM8760236 MAR1_sample2 MAR1_sample
- GSM8760237 MAR1_sample3 MAR1_sample
- GSM8760238 Normal_sample1 Normal_sample
- GSM8760239 Normal_sample2 Normal_sample
- GSM8761973 Normal
- GSM8761974 OXA_d10 OXA_d
- GSM8761975 MC903_d9
- GSM8761976 OXA_d16 OXA_d
- GSE290434 A stress response axis in tumor-associated macrophages dictates phenotype heterogeneity and immunotherapy evasion 21 samples shares axis, type
- GSE269507 The interleukin 22–oncostatin M axis promotes intestinal inflammation and tumorigenesis [scRNA-seq] 12 samples shares axis
- GSE297412 Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury 12 samples shares axis
- GSE221283 Parenchymal damage and myeloid inflammation link the Rag GTPase – mTORC1 axis to mammalian aging [old] 10 samples shares axis
- GSE304706 Persistent ER stress in macrophages fuels age-related inflammation and vulnerability to infection 8 samples shares fuels
- GSE329024 Distinct HPO axis responses to chronic unpredictable stress in young versus adult female mice 63 samples shares axis
- GSE243008 Mitochondrial serine metabolism fuels epigenetic remodelling in osteoclast differentiation and is the main target of methotrexate 58 samples shares fuels
- GSE330442 Impact of Reduced Maternal Tryptophan on the Placenta-Brain Axis 41 samples shares axis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.