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Therapeutic effect of ANGPTL4 antisense oligonucleotide treatment in pneumonia caused by PAO1 bacteria or PR8 virus

GSE288259 Mus musculus (mouse) RNA-seq (gene expression) 41 samples Submitted 2026/03/24 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 41 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
41 samples: 25 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and FibrosisAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Summary (written by the submitters)
A bacterial pneumonia model represented by Pseudomonas aeruginosa (PAO1) or viral pneumonia model by PR8 virus infection were constructed, and then the drug of antisense oligonucleotide(ASO) for ANGPTL4 is administered for treatment. The inflammatory status of mouse lung tissue is analyzed pathologically and the inflammatory cell count is carried out to evaluate the therapeutic effect of the drug.
Read the full summary ↓
Similarly, the expression of ANGPTL4 protein in mice is detected and its corresponding lung tissues are analyzed for transcriptomic analysis, and its possible functional pathways are further explored and summarized.
Published in
Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis
Fan H, Tan Y, Zhang J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41869866 · doi:10.1002/advs.202501909
This dataset
Open GSE288259 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288259_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1216642 and SRA study SRP560456. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41869866) ↗
Study design
25 distinct titles, 4 of them repeated
Mock-ASO-M ×5 Mock-Mock-M ×5 PAO-ASO-M ×5 PAO-Mock-M ×5

How we read this: Read from 41 sample titles: 25 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 1 more — browse all 41 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.