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Endogenous retroviruses promote aberrant T cell differentiation in systemic lupus erythematosus via the RIG-I pathway [naïve]

GSE288272 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/18 Platform GPL24676
Summary
The dysregulated differentiation of T lymphocytes play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Our findings reveal many overexpressed HERVs in CD4+ T cells from SLE patients. To investigate the role of dsRNA/RIG-I pathway in CD4+ T cell differentiation, RNA-seq was performed in CD3 and CD28 antibodies activated naive CD4+ T cells transfected with poly(I:C). The expression profiles of genes related to the effector T cell differentiation reveal that dsRNAs induced the activation of the RIG-I signaling pathway plays important roles in aberrant differentiation of T cells.
Published in
DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway
Min X, Yu Y, Hu Z et al. · EBioMedicine 2025 · PMID 40992212 · doi:10.1016/j.ebiom.2025.105934
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Also filed as BioProject PRJNA1216658 and SRA study SRP560470. Searching any of these in the dataset finder brings you back here.

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