EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the pre-metastatic niche to promote TNBC metastasis
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasisScience advances · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288338_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216955 and SRA study SRP560520. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8763817 66cl4 SCR Biological Replicate 1 66cl4 SCR
- GSM8763818 66cl4 SCR Biological Replicate 2 66cl4 SCR
- GSM8763819 66cl4 SCR Biological Replicate 3 66cl4 SCR
- GSM8763820 66cl4 shEya3 KD1 Biological Replicate 1 66cl4 shEya3 KD1
- GSM8763821 66cl4 shEya3 KD1 Biological Replicate 2 66cl4 shEya3 KD1
- GSM8763822 66cl4 shEya3 KD1 Biological Replicate 3 66cl4 shEya3 KD1
- GSM8763823 66cl4 shEya3 KD2 Biological Replicate 1 66cl4 shEya3 KD2
- GSM8763824 66cl4 shEya3 KD2 Biological Replicate 2 66cl4 shEya3 KD2
- GSM8763825 66cl4 shEya3 KD2 Biological Replicate 3 66cl4 shEya3 KD2
- GSM8763826 66cl4 SCR+Empty Vector Biological Replicate 1 66cl4 SCR+Empty Vector
- GSM8763827 66cl4 SCR+Empty Vector Biological Replicate 2 66cl4 SCR+Empty Vector
- GSM8763828 66cl4 SCR+Empty Vector Biological Replicate 3 66cl4 SCR+Empty Vector
- GSM8763829 66cl4 shEya3 KD2 + Empty Vector Biological Replicate 1 66cl4 shEya3 KD2 + Empt…
- GSM8763830 66cl4 shEya3 KD2 + Empty Vector Biological Replicate 2 66cl4 shEya3 KD2 + Empt…
- GSM8763831 66cl4 shEya3 KD2 + Empty Vector Biological Replicate 3 66cl4 shEya3 KD2 + Empt…
- GSM8763832 66cl4 shEya3 KD2 + IKK2-SE Biological Replicate 1 66cl4 shEya3 KD2 + IKK2…
- GSM8763833 66cl4 shEya3 KD2 + IKK2-SE Biological Replicate 2 66cl4 shEya3 KD2 + IKK2…
- GSM8763834 66cl4 shEya3 KD2 + IKK2-SE Biological Replicate 3 66cl4 shEya3 KD2 + IKK2…
- GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples shares nf
- GSE294911 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14] 1000 samples shares nf
- GSE316925 Transcriptome changes in trigeminal ganglia in the mouse chronic constriction injury of the infraorbital nerve model - role of TRPM3. 136 samples shares nf
- GSE176506 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease 112 samples shares nf
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares nf
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares nf
- GSE299114 Endothelial Cells retain inflammatory memory through chromatin remodeling [RNA-Seq 2] 53 samples shares nf
- GSE338894 An orally active, gut-enriched AhR agonist demonstrates therapeutic efficacy in colitis through regulation of inflammation, barrier homeostasis, and fibrosis 50 samples shares nf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.