← BioTransfer GEO Dataset Finder
GEO series

Effect of depletion of FAT4 on gene expression in A673 Ewing sarcoma cells

GSE288384 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/01 Platform GPL21290
Summary
Ewing sarcoma is a cancer of bone and soft tissue in children characterized by a chromosomal translocation that fuses EWS and an ETS family transcription factor, most commonly FLI1. EWS-FLI1 is the driver of this cancer. Using secretome proteomics and molecular cell biology, we found that FAT4, an atypical cadherin inhibiting Hippo signaling, is a transcriptional target of EWS-FLI and is a dependency in Ewing sarcoma. We used RNA-sequencing to determine the gene expression changes caused by FAT4 silencing in Ewing sarcoma cells.
Published in
Ewing sarcoma depends on C4orf48/NICOL, a NELL2 cofactor regulated by Hippo signaling
Jayabal P, Ma X, Chen Y et al. · Cellular signalling 2025 · PMID 40451561 · doi:10.1016/j.cellsig.2025.111904
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE288384_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1217337 and SRA study SRP560704. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.