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Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking.

GSE288410 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2025/03/24 Platform GPL24247
Summary
Angiotensin Converting Enzyme (ACE) has been studied for its role in the regulation of myeloid cell bactericidal and antitumor activity. Here, we generated a mouse model with Tamoxifen-dependent ACE expression with Cx3CR1-Cre control. These mice were crossed to 5xFAD and 9 month forebrains were harvested for their nuclei to assess the ACE-dependent changes in amyloid-reactive microglia.
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Also filed as BioProject PRJNA1217393 and SRA study SRP560771. Searching any of these in the dataset finder brings you back here.

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