Transcriptome Response to Autoantibodies in Human Primary Epidermis Keratinocyte Model for Pemphgus Vulgaris
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288492_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1217866 and SRA study SRP560908. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8768964 2D_hIgG_5h_1 2D_hIgG_5h
- GSM8768965 2D_hIgG_5h_2 2D_hIgG_5h
- GSM8768966 2D_hIgG_5h_3 2D_hIgG_5h
- GSM8768967 2D_PX43_5h_1 2D_PX43_5h
- GSM8768968 2D_PX43_5h_2 2D_PX43_5h
- GSM8768969 2D_PX43_5h_3 2D_PX43_5h
- GSM8768970 2D_hIgG_10h_1 2D_hIgG_10h
- GSM8768971 2D_hIgG_10h_2 2D_hIgG_10h
- GSM8768972 2D_hIgG_10h_3 2D_hIgG_10h
- GSM8768973 2D_PX43_10h_1 2D_PX43_10h
- GSM8768974 2D_PX43_10h_2 2D_PX43_10h
- GSM8768975 2D_PX43_10h_3 2D_PX43_10h
- GSM8768976 2D_hIgG_24h_1 2D_hIgG_24h
- GSM8768977 2D_hIgG_24h_2 2D_hIgG_24h
- GSM8768978 2D_hIgG_24h_3 2D_hIgG_24h
- GSM8768979 2D_PX43_24h_1 2D_PX43_24h
- GSM8768980 2D_PX43_24h_2 2D_PX43_24h
- GSM8768981 2D_PX43_24h_3 2D_PX43_24h
- GSM8768982 2D_hIgG_48h_1 2D_hIgG_48h
- GSM8768983 2D_hIgG_48h_2 2D_hIgG_48h
- GSM8768984 2D_hIgG_48h_3 2D_hIgG_48h
- GSM8768985 2D_PX43_48h_1 2D_PX43_48h
- GSM8768986 2D_PX43_48h_2 2D_PX43_48h
- GSM8768987 2D_PX43_48h_3 2D_PX43_48h
- GSE285008 Transcriptome Response and Protein Abundance are Correlated with Split Formation and Cell Detachment as Secondary Effects to Autoantibodies in Human Skin Organ Culture Models for Pemphgus Vulgaris 78 samples shares autoantibodies, pemphgus, vulgaris
- GSE276844 3D model of human epidermis exposed to Staphylococci reveals keratinocyte responses unique to atopy-associated S. aureus challenge. 8 samples shares keratinocyte, epidermis
- GSE305980 Primary Keratinocyte Model of Actinic Keratosis Reveals UV-Induced DNA Damage Accumulation and Persistent Interferon Signaling 42 samples shares keratinocyte, primary
- GSE324594 Transcriptomic changes in primary human keratinocytes following exposure to lamotrigine, lamotrigine-N2-oxide, lamotrigine in combination with valproic acid or interferon-γ, and interferon-γ alone 36 samples shares keratinocyte, primary
- GSE315599 Primary human fibroblasts and keratinocytes stimulated with IL-17A and/or TNF 32 samples shares keratinocyte, primary
- GSE319393 Analysis of gene expression in primary human foreskin keratinocytes (HFK) +/- HPV16 or HPV6 E7 15 samples shares keratinocyte, primary
- GSE280620 Bulk RNA-seq of primary keratinocytes treated with IgG from patients with bullous pemphigoid or controls II 14 samples shares keratinocyte, primary
- GSE272321 Effect of depletion of PNPLA1 in gene expression during keratinocyte differentiation on reconstructed human epidermis 12 samples shares keratinocyte, epidermis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.