Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis
RNA-seq (gene expression) · human · 40 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 40 samples: 10 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensisbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288527_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1217935 and SRA study SRP560977. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 40 samples.
How we read this: 10 replicated groups read from 40 sample titles; they account for 40 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8769413 A549 untreated rep1 A549 untreated
- GSM8769414 A549 6h IFNg rep1 A549 6h IFNg
- GSM8769415 A549 untreated rep2 A549 untreated
- GSM8769416 A549 6h IFNg rep2 A549 6h IFNg
- GSM8769417 A549 untreated rep3 A549 untreated
- GSM8769418 A549 6h IFNg rep3 A549 6h IFNg
- GSM8769419 A549 untreated rep4 A549 untreated
- GSM8769420 A549 6h IFNg rep4 A549 6h IFNg
- GSM8769421 HeLa untreated rep1 HeLa untreated
- GSM8769422 HeLa 6h IFNg rep1 HeLa 6h IFNg
- GSM8769423 HeLa untreated rep2 HeLa untreated
- GSM8769424 HeLa 6h IFNg rep2 HeLa 6h IFNg
- GSM8769425 HeLa untreated rep3 HeLa untreated
- GSM8769426 HeLa 6h IFNg rep3 HeLa 6h IFNg
- GSM8769427 HeLa untreated rep4 HeLa untreated
- GSM8769428 HeLa 6h IFNg rep4 HeLa 6h IFNg
- GSM8769429 T24 untreated rep1 T24 untreated
- GSM8769430 T24 6h IFNg rep1 T24 6h IFNg
- GSM8769431 T24 untreated rep2 T24 untreated
- GSM8769432 T24 6h IFNg rep2 T24 6h IFNg
- GSM8769433 T24 untreated rep3 T24 untreated
- GSM8769434 T24 6h IFNg rep3 T24 6h IFNg
- GSM8769435 T24 untreated rep4 T24 untreated
- GSM8769436 T24 6h IFNg rep4 T24 6h IFNg
- GSM8769437 THP1 untreated rep1 THP1 untreated
- GSM8769438 THP1 6h IFNg rep1 THP1 6h IFNg
- GSM8769439 THP1 untreated rep2 THP1 untreated
- GSM8769440 THP1 6h IFNg rep2 THP1 6h IFNg
- GSM8769441 THP1 untreated rep3 THP1 untreated
- GSM8769442 THP1 6h IFNg rep3 THP1 6h IFNg
- GSM8769443 THP1 untreated rep4 THP1 untreated
- GSM8769444 THP1 6h IFNg rep4 THP1 6h IFNg
- GSM8769445 U937 untreated rep1 U937 untreated
- GSM8769446 U937 6h IFNg rep1 U937 6h IFNg
- GSM8769447 U937 untreated rep2 U937 untreated
- GSM8769448 U937 6h IFNg rep2 U937 6h IFNg
- GSM8769449 U937 untreated rep3 U937 untreated
- GSM8769450 U937 6h IFNg rep3 U937 6h IFNg
- GSM8769451 U937 untreated rep4 U937 untreated
- GSM8769452 U937 6h IFNg rep4 U937 6h IFNg
- GSE318734 Host-directed microRNA-based intervention against intracellular Staphylococcus aureus: High-throughput screening identifies miR-4430, miR-147a, and miR-1249-5p as multifunctional antimicrobial candidates 12 samples shares antimicrobial, intracellular
- GSE328276 Host-pathogen dual targeting with repurposed drugs identifies a synergistic therapy for intracellular Staphylococcus aureus 6 samples shares intracellular, pathogen
- GSE279027 Limited proteolysis of neutrophil granule proteins by the bacterial protease RgpB 2 depletes neutrophil antimicrobial capacity 5 samples shares antimicrobial, bacterial
- GSE312934 Mycobacterial Metallophosphatase MmpE Functions as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival 4 samples shares intracellular, bacterial
- GSE297004 Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease 53 samples shares intracellular
- GSE280021 Dynamics of Th1/Th17 Responses and Antimicrobial Pathways in Leprosy Skin Lesions 45 samples shares antimicrobial
- GSE186207 Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene 36 samples shares intracellular
- GSE328400 Optical Screening Identifies Chemical Modulators of Intracellular α-synuclein Aggregation 24 samples shares intracellular
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.