ULK1 as a novel therapeutic target in Myeloproliferative Neoplasms [RNA-Seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Myeloproliferative neoplasmsThis series is part of our curated briefing on it.
- Samples
- 12 samples: 4 × Ctrl vs 4 × SBI vs 4 × ULK101Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative NeoplasmsMolecular and cellular biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288557_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1218432 and SRA study SRP561096. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8769830 Ctrl_rep1 Ctrl
- GSM8769831 Ctrl_rep2 Ctrl
- GSM8769832 Ctrl_rep3 Ctrl
- GSM8769833 Ctrl_rep4 Ctrl
- GSM8769834 SBI_rep1 SBI
- GSM8769835 SBI_rep2 SBI
- GSM8769836 SBI_rep3 SBI
- GSM8769837 SBI_rep4 SBI
- GSM8769838 ULK101_rep1 ULK101
- GSM8769839 ULK101_rep2 ULK101
- GSM8769840 ULK101_rep3 ULK101
- GSM8769841 ULK101_rep4 ULK101
- GSE327733 Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms [RNA-Seq] 10 samples same disease briefing · shares myeloproliferative, therapeutic, neoplasms, rna-seq, target
- GSE327732 Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms [scRNA-Seq] 4 samples same disease briefing · shares myeloproliferative, therapeutic, neoplasms, rna-seq, target
- GSE252715 CPL mitigates myeloproliferative neoplasms through dual targeting of cell senescence and NF-κB signaling 6 samples same disease briefing · shares myeloproliferative, neoplasms, target
- GSE277354 Genetic charcterization of myeloproliferative neoplasms (MPN) 402 samples same disease briefing · shares myeloproliferative, neoplasms
- GSE288386 Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms 37 samples same disease briefing · shares myeloproliferative, neoplasms
- GSE301154 Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase 32 samples same disease briefing · shares myeloproliferative, neoplasms
- GSE309082 Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms 29 samples same disease briefing · shares myeloproliferative, neoplasms
- GSE308705 Non-Invasive Detection of Bone Marrow Fibrosis in Myeloproliferative Neoplasms Using Cell-Free RNA 16 samples same disease briefing · shares myeloproliferative, neoplasms
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.