GEO series
RNA-seq from atirmociclib resistant versus sensitive and vehicle treated HR+ HER2- ZR751 breast cancer xenografts .
GSE288580
Homo sapiens
Expression profiling by high throughput sequencing
26 samples
2025/03/31
GPL30173
Summary
We investigated the mechanisms of acquired resistance to the CDK4 selective inhibitor atirmociclib in HR+ HER2- breast cancer in vivo, using the ZR751 xenograft model. Atirmociclib resistant tumors appeared after long-term (>50 day) treatment with atirmociclib. Tumor material was isolated from resistant (85-day treatment) as well as sensitive/vehicle treated (3-day) tumor bearing mice and subjected to RNA-seq analysis.
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Paper (PMID 40068598) ↗
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