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GPNMB is a marker of invasive quiescent differentiated melanoma cells driven by tumor niche reprogramming

GSE288622 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/29 Platform GPL24676
Summary
We provide evidence of the existence of a slow cycling melanoma population isolated in vivo from melanoma PDXs using the H2B-GFP system. Single cell transcriptomic analysis unveils a significant transcriptional heterogeneity of GFP-retaining slow cycling cells, defining a quiescent subpopulation of cells. These cells show a different phenotype in primary tumors and matched metastases, suggesting that tumor niche pressure drives a transcriptional reprogramming of quiescent cells during melanoma progression.
Published in
GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation
Lotti F, Melixetian M, Vlachou T et al. · EMBO reports 2025 · PMID 40528051 · doi:10.1038/s44319-025-00501-w
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Also filed as BioProject PRJNA1218712 and SRA study SRP561325. Searching any of these in the dataset finder brings you back here.

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