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Transcriptomic analysis of Hela Ezrin Ko cells

GSE288769 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2025/09/30 Platform GPL24676
Summary
Ezrin (EZR), a cell membrane to cytoskeleton linker protein, plays key roles in maintaining cellular homeostasis. Its deregulation at various levels strongly correlates with cancer progression, metastasis and higher patient mortality. However, the precise mechanistic basis for its role remains unknown. Recently, we demonstrated that Ezrin participates in EGFR/AKT signaling pathways. Importantly, transitions between active (phosphorylated open) and inactive (dephosphorylated closed) forms of Ezrin is crucial for its function in cancer. Gene expression analysis suggested dysregulation of genes that are functionally linked to cell energetic metabolism with potential implications for cell proliferation, survival and apoptosis. Total RNA was extracted from n=4 for each experimantal group: Transcriptomic analysis was performed on HeLa WT and HeLa Ezrin KO cells.
Published in
Loss of Ezrin triggers mitochondrial dysfunction and oxidative stress, associated with neuronal cell death
Giamundo G, Carratù I, Barone C et al. · Cell death discovery 2025 · PMID 41145430 · doi:10.1038/s41420-025-02790-5
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Also filed as BioProject PRJNA1219224 and SRA study SRP561577. Searching any of these in the dataset finder brings you back here.

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