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Akkermansia muciniphila outer membrane protein Amuc_0904 promotes goblet cell differentiation

GSE288821 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/05 Platform GPL24676
Summary
Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.
Published in
Akkermansia muciniphila outer membrane protein Amuc_0904 modulates intestinal homeostasis by promoting goblet cell differentiation
Yang L, Yang J, Kong X et al. · Gut microbes 2026 · PMID 41424360 · doi:10.1080/19490976.2025.2587405
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Also filed as BioProject PRJNA1219556 and SRA study SRP561766. Searching any of these in the dataset finder brings you back here.

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