Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289048_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1220699 and SRA study SRP562254. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8782593 H520_PBS_rep1, RNA-seq
- GSM8782594 H520_PBS_rep2, RNA-seq
- GSM8782595 H520_PBS_rep3, RNA-seq
- GSM8782596 H520_CDDP_rep1, RNA-seq
- GSM8782597 H520_CDDP_rep2, RNA-seq
- GSM8782598 H520_CDDP_rep3, RNA-seq
- GSM8782599 H520, input, CUT&Run
- GSM8782600 H520, SOX2, CUT&Run
- GSM9400186 H520, Vehicle,SOX2, CUT&Run
- GSM9400187 H520, Hx1,SOX2, CUT&Run
- GSM9400231 H520_Vehicle_rep1, RNA-seq
- GSM9400232 H520_Vehicle_rep2, RNA-seq
- GSM9400233 H520_Hx1_rep1, RNA-seq
- GSM9400234 H520_Hx1_rep2, RNA-seq
- GSE289045 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq] 6 samples shares sox2, self-association, chemotherapeutic, condensates, disrupting, resistance, overcome, squamous
- GSE314519 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq, 2] 4 samples shares sox2, self-association, chemotherapeutic, condensates, disrupting, resistance, overcome, squamous
- GSE314516 Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [Cut & Run, 2] 2 samples shares sox2, self-association, chemotherapeutic, condensates, disrupting, resistance, overcome, squamous
- GSE299313 SOX2 Binds to CD133 in Glioblastoma Stem Cells to Regulate Cellular Stress Pathways Underlying Treatment Resistance 24 samples shares sox2, resistance
- GSE256475 SOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape 16 samples shares sox2, squamous
- GSE291583 IQGAP3 bridges matrix stiffness with cancer stem cell maintenance and radioresistance by stabilizing SOX2 II 16 samples shares sox2, resistance
- GSE256473 SOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape (ChIP-seq) 10 samples shares sox2, squamous
- GSE253468 DUSP1 and SOX2 expression determine Squamous cell carcinoma of the salivary gland progression. 10 samples shares sox2, squamous
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.