Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytesFrontiers in pharmacology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289113_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1221568 and SRA study SRP562717. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8783909 Hacat cell, control 1 Hacat cell, control
- GSM8783910 Hacat cell, control 2 Hacat cell, control
- GSM8783911 Hacat cell, control 3 Hacat cell, control
- GSM8783912 Hacat cell, UVB1 Hacat cell, UVB
- GSM8783913 Hacat cell, UVB2 Hacat cell, UVB
- GSM8783914 Hacat cell, UVB3 Hacat cell, UVB
- GSM8783915 Hacat cell, ROL1 Hacat cell, ROL
- GSM8783916 Hacat cell, ROL2 Hacat cell, ROL
- GSM8783917 Hacat cell, ROL3 Hacat cell, ROL
- GSM8783918 Hacat cell, Rplam1 Hacat cell, Rplam
- GSM8783919 Hacat cell, Rplam2 Hacat cell, Rplam
- GSM8783920 Hacat cell, Rplam3 Hacat cell, Rplam
- GSM8783921 Hacat cell, RR1 Hacat cell, R
- GSM8783922 Hacat cell, RR2 Hacat cell, R
- GSM8783923 Hacat cell, RR3 Hacat cell, R
- GSE315878 Lack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer 70 samples shares recombination, homologous
- GSE299349 Targeting ATR signaling in sarcoma with homologous recombination deficiency 68 samples shares recombination, homologous
- GSE222556 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors [10x scRNA-seq] 67 samples shares recombination, homologous
- GSE295599 Combinatorial delivery of low-dose irradiation and immunotherapy to patients with immune-excluded tumors effectively enhances CD8+ T cell functionality in tumors with homologous recombination repair deficiency [bulk RNA-seq] 29 samples shares recombination, homologous
- GSE295600 Combinatorial delivery of low-dose irradiation and immunotherapy to patients with immune-excluded tumors effectively enhances CD8+ T cell functionality in tumors with homologous recombination repair deficiency [scRNA-seq] 18 samples shares recombination, homologous
- GSE289437 PARP inhibitors elicit distinct transcriptional programs in homologous recombination repair competent castrate resistant prostate cancer 18 samples shares recombination, homologous
- GSE289735 Alpha-ketoglutarate -mediated carnitine synthesis promotes homologous recombination via histone acetylation 12 samples shares recombination, homologous
- GSE269793 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors [Singleron scRNA-seq] 10 samples shares recombination, homologous
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.