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Lactate-mediated histone lactylation promotes melanoma angiogenesis

GSE289136 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/02 Platform GPL24676
Summary
The pathogenesis of cancer is rather complicated and includes multiple aspects, with metabolic reprogramming and angiogenesis as the leading hallmark characteristics. Recent reports have unveiled that the glycolytic metabolite lactate could modify histone lactylation level to epigenetically regulate gene expressions and biological processes in cancer, while the role of lactate-mediated histone lactylation in tumor angiogenesis remains elusive. By taking advantage of melanoma as the model, we demonstrate that lactate-mediated histone lactylation promotes tumor angiogenesis via IL-33/ST2 axis.
Published in
Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis
Zhao M, Qian Y, He L et al. · Cell death & disease 2025 · PMID 41053006 · doi:10.1038/s41419-025-08023-y
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Also filed as BioProject PRJNA1221789 and SRA study SRP562815. Searching any of these in the dataset finder brings you back here.

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