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The role and mechanism of hypoxia in regulating parthanatos in hepatocellular carcinoma

GSE289258 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/23 Platform GPL29480
Summary
Recently, a PARP1-dependent cell-death process termed "parthanatos", driven by DNA damage, has emerged as a crucial regulator of tissue homeostasis and tumorigenesis. Hypoxia is a hallmark of solid tumors and profoundly affects the malignant phenotypes of cancer cells. The crosstalk between parthanatos and hypoxia remains poorly understood. In our study, we find that despite causing DNA damage, hypoxia fails to induce parthanatos in HCC. Transcriptome sequencing upon MNNG stimulation indicated that the creatine transporter solute carrier family 6, member 8 (SLC6A8) was involved in parthanatos antagonism and malignant phenotypes in hypoxic HCC cells.
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Also filed as BioProject PRJNA1222278 and SRA study SRP563146. Searching any of these in the dataset finder brings you back here.

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