GEO series
Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction
GSE289265
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/06/05
GPL34328
Summary
Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associated with a poor outcome. Pathological gene expressions in heart failure are accompanied by changes in active histone marks without major alterations in DNA methylation. Whether chromatin modifications participate to obesity-induced HFpEF is largely unknown. We will investigate whether chromatin marks participate to obesity-induced HFpEF in vivo.
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Paper (PMID 40211947) ↗
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