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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (RNA-seq)

GSE289277 Homo sapiens Expression profiling by high throughput sequencing; Other 8 samples Submitted 2025/08/07 Platform GPL18573
Summary
Breast cancer is the most common cancer in women worldwide. SETD1A, a histone H3 lysine-4 methyltransferase, is associated with poor prognosis in breast cancer. While both its enzymatic and non-enzymatic functions have been implicated in cancer progression, the specific role of SETD1A in breast cancer remains unclear. This study aimed to elucidate the molecular mechanisms underlying SETD1A dependency in breast cancer.
Published in
Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K
Hayashi K, Hoshii T, Ning M et al. · Breast cancer research : BCR 2025 · PMID 40790603 · doi:10.1186/s13058-025-02101-x
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Direct links to NCBI, no account and no request form: the whole study as GSE289277_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1222330 and SRA study SRP563182. Searching any of these in the dataset finder brings you back here.

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