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Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Cardiometabolic Heart Failure with Preserved Ejection Fraction

GSE289331 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/02/12 Platform GPL24247
Summary
Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associated with a poor outcome. Pathological gene expressions in heart failure are accompanied by changes in active histone marks without major alterations in DNA methylation. Histone 3 trimethylation at lysine 36 (H3k36me3) - a chromatin signature induced by the histone methyltransferase SETD2 – has shown a strong correlation with changes in gene expression in the human failing heart; yet its role in cardiac disease is poorly understood. The present study investigates the role of SETD2/ H3k36me3 in cHFpEF.
Published in
Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF
Costantino S, Mohammed SA, Ambrosini S et al. · Circulation research 2025 · PMID 40211947 · doi:10.1161/CIRCRESAHA.124.325310
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Also filed as BioProject PRJNA1222432 and SRA study SRP563275. Searching any of these in the dataset finder brings you back here.

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